CYTOCHEMISTRY IN THE DIFFERENTIAL DIAGNOSIS OF MONOCLONAL GAMMOPATHIES
نویسندگان
چکیده
منابع مشابه
Monoclonal gammopathies
Clinical background The finding of a monoclonal immunoglobulin in the serum defines the so-called monoclonal gammopathy. Monoclonal components are homogeneus immunoglobulins whole (intact) or fragmented, produced by a single expanded plasma cell clone. MCs present unique physicochemical homogeneity, which is reflected in their immunological homogeinity. Immunological homogeinity by electrophore...
متن کاملThe monoclonal gammopathies.
Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M-proteins. Immunoelectrophoresis should be performed when myeloma, m...
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Sixty-two patients affected by MGUS underwent fat tissue aspirate examination for diagnosis of AL amyloidosis. Nine out of the 62 were found to be Congo red positive. MGUS had already been diagnosed for quite a long time in about 60% of these patients, while this prevalence decreased to 24% among the Congo red negative patients. The follow-up of the positive patients is reported.
متن کاملMonoclonal gammopathies in chest disease.
Monoclonal gammopathies are found in patients with myeloma, lymphoid malignant disorders, and amyloidosis. They are also discovered in patients with other diseases, and even in healthy people over 70 years.' 2 In such cases monoclonal gammopathies are of undetermined significance, and therefore of little if any diagnostic value. The aim of the present study was to evaluate the monoclonal gammop...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1985
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1985.tb07483.x